[Weekly and daily intake of alendronate: comparison of tolerance in osteoporosis treatment].
نویسندگان
چکیده
In this study we analyzed, considering complains of patients, tolerance of taking alendronate 70 mg once a week in comparison with daily intake of alendronate 10 mg. Subjects were patients that were treated for osteoporosis at Department for physical medicine and rehabilitation in Clinical hospital Dubrava. The diagnosis of osteoporosis was established by DXA densitometry. Pains in oesophagus were the main reason for ceasing of use of alondronate. According to our research patients tolerate taking alendronate 70 weekly 4,22 times better than alendronate 10 daily.
منابع مشابه
[Alendronate and vitamin D (Fosavance): persistence, adherence and importance of vitamin D].
Persistence and adherence are major determinants of optimal results in the treatment of osteoporosis. In order to improve the efficacy of antiresorptive drugs, fewer demands on patients and better adherence were obtained with less frequent dosing schedule. Once-weekly and once-monthly oral bisphophonates showed equivalency with once daily medications. Comparison of persistence and adherence bet...
متن کاملPatients with osteoporosis prefer once weekly to once daily dosing with alendronate.
OBJECTIVES Once weekly dosing of alendronate has been shown to provide equivalent efficacy to once daily dosing for treatment of osteoporosis in postmenopausal women. Whether patients will prefer weekly dosing to daily dosing for a chronic condition such as osteoporosis has not been studied. The aim of this international study was to assess preference for the weekly or daily dosing regimen of a...
متن کاملاثر تزریق داروی سینوپار بر تراکم استخوانی زنان یائسه مبتلا به استئوپروزیس
Background and purpose: Osteoporosis is the most common metabolic bone disease. The aim of this study was to evaluate the effects of teriparatide on the incidence of fractures and bone density in postmenopausal women with osteoporosis. Materials and methods: A clinical trial was performed in all postmenopausal women aged 45-75 years old with osteoporosis attending a teaching hospital affiliate...
متن کاملEffects of pentoxifylline and alendronate on fracture healing in ovariectomy-induced osteoporosis in rats
Osteoporosis is determined by decreased bone strength that increases the threat of fractures. The aim of this study was to evaluate the effects of pentoxifylline (PTX) and alendronate (ALN), on the stereological parameters, and gene expression in callus of fracture in an experimental rat model of ovariectomy-induced osteoporosis (OVX). The OVX was induced in 90 female rats. Fourteen weeks later...
متن کاملTherapeutic equivalence of alendronate 70 mg once-weekly and alendronate 10 mg daily in the treatment of osteoporosis. Alendronate Once-Weekly Study Group.
Dosing convenience is a key element in the effective management of any chronic disease, and is particularly important in the long-term management of osteoporosis. Less frequent dosing with any medication may enhance compliance, thereby maximizing the effectiveness of therapy. Animal data support the rationale that once-weekly dosing with alendronate 70 mg (7 times the daily oral treatment dose)...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Reumatizam
دوره 51 1 شماره
صفحات -
تاریخ انتشار 2004